{"id":3191,"date":"2020-11-27T11:31:59","date_gmt":"2020-11-27T11:31:59","guid":{"rendered":"https:\/\/www.integracosmetics.com\/cao\/skin-compatibility\/"},"modified":"2021-06-10T19:50:33","modified_gmt":"2021-06-10T19:50:33","slug":"skin-compatibility","status":"publish","type":"page","link":"https:\/\/www.integracosmetics.com\/en\/cao\/skin-compatibility\/","title":{"rendered":"Skin compatibility"},"content":{"rendered":"\t\t
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Skin compatibility<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Home<\/a><\/span><\/span><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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A strategy consisting of a preliminary in vitro in vitro test with the Dermal irritection\u00ae<\/a><\/strong> method and a subsequent skin test<\/em>with the use of Patch tests at 48 hours of exposure on 12 volunteers.<\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The benefits<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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  • Get more comprehensive results for the product safety evaluator.<\/li>\n
  • Reduce the time needed to obtain information: the preliminary result provides important information within a few days.<\/li>\n<\/ul>\n
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    • Reduce the number of volunteers in the analysis laboratory to a minimum. They will be better protected, reducing the possibility of infection by Covid-19.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      The testing strategy<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      Normally, in the EU Commission’s guidelines for good laboratory practices, a preliminary in vitro test is required before performing Patch Tests on volunteers.<\/p>\n

      Our preliminary in vitro test is not a simple cytotoxicological test<\/strong>, but a real in vitro skin irritation test, based on a solid scientific basis, and with sustainable time and cost savings.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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      \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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      The subsequent dermatological test will then serve to provide additional information<\/strong> and can be conducted on a small number of volunteers, given that they will be kept under exam for 48 hours, with the same reliability as if the test had been executed with a bigger volunteer pool.<\/p>\n

      The strategy says that:<\/p>\n

      – If the result of the preliminary is “non-irritant”<\/em>the test on volunteers can be executed for confirmation purposes.<\/p>\n

      – If the result is clearly “irritant”<\/em> it will not be necessary to continue the testing on volunteers.<\/p>\n

      – if the result is “borderline”<\/em> , in case of products that can be placed on the market even if they have a moderate to medium degree of irritation, the volunteer test will be used to investigate the degree of irritation.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

      Skin compatibility A strategy consisting of a preliminary in vitro in vitro test with the Dermal irritection\u00ae method and a subsequent skin testwith the use of Patch tests at 48 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1334,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"class_list":["post-3191","page","type-page","status-publish","hentry"],"yoast_head":"\nSkin compatibility - INT.E.G.RA.<\/title>\n<meta name=\"description\" content=\"In vitro and in vivo testing strategy, on reduced number of volunteers, for more comprehensive and faster results for the safety evaluator.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.integracosmetics.com\/en\/cao\/skin-compatibility\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Skin compatibility - 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