Custom Analysis Organization

Una strategia di testing completa

Sicurezza dei risultati, rapidità di elaborazione ed economicità dei propri sforzi, sono questi i motivi primari che spingono i nostri clienti ad affidarsi a noi.
CAO si è sempre occupato di test in vitro con l’obiettivo di soddisfare i bisogni dell’industria cosmetica e di dimostrare la sicurezza e l’efficacia dei propri prodotti.
Forti del nostro know-how in materia, abbiamo deciso, per completare l’offerta e per ridurre ancora di più gli sprechi, di introdurre nella nostra offerta anche altri metodi d’indagine come, per esempio, il test su volontari. I test su volontari saranno utilizzati solamente in coda ai test alternativi proposti nella strategia di testing e avranno lo scopo di conferma della sicurezza e dell’efficacia, ponendo i volontari a minor rischio rispetto alle pratiche consolidate dell’industria.

The importance of a correct testing strategy

In the creation of a product, one of the critical success factors, even more than its attractiveness on the market, is its safety towards the consumer.  In accordance with Regulation 1223/2009, companies are committed to placing the health of the end user at the center of decisions throughout the cosmetic chain.

I nostri laboratori effettuano strategie di testing Custom Made create appositamente attorno alle peculiarità di ogni singolo prodotto testato.

In verifying the safety of your product, our laboratories implement the best and most advanced in vivo and in vitro testing strategies to ensure the best possible results and analysis..

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To evaluate the effectiveness of products e dispositivi destinati all’uomo e studiarne i propri meccanismi d’azione, C.A.O. si avvale sia di strumenti d’analisi sviluppati in collborazione con DISTAV che di quelli adottati adottati dalla comunità internazionale. 

Why decide for yourself if your customers will be the ones buying?

The consumer panel of our Beauty & Wellness Community is ready to test your product before it reaches the market. 

Modelli etici, nuovi test

INT.E.G.RA. e il DISTAV, il Dipartimento di Scienze della Terra, dell’Ambiente e della Vita dell’Università di Genova, collaborano insieme nella ricerca, messa a punto  e validazione di test in vitro per determinare gli effetti benefici di cosmetici: ringenerativi, rimarginativi e antiossidanti.

Test alternativi

In vitro skin irritation test on the samples supplied using the Dermal IRRITECTION® method

In vitro eye irritation test on samples supplied using Protocol DB-ALM 157
IRRITECTION®, OECD APPROVED 496.

In vitro eye-irritation test. Ocular IRRITECTION® protocol.

Dermal Corrosivity in vitro TEST. Protocol Corrositex®; OECD 435.

Vitality tests on various celliular lines (HaCaT, HECV, macrofagi-raw 264.7, CCD-1070Sk, MCF7, FaO).

ASSESSMENT OF THE IRRITANT POWER ON SKIN using reconstituted skin according to
protocol guideline OECD 439

EVALUATION OF IRRITANT POWER (coloured substances) by using reconstituted skin
according to OECD Guideline 439 protocol.

Test tube: DPPH (α, α-diphenyl-β-picrylhydrazyl) assay (Kedare et al. 2011).

Quantification of free radicals in cell models: HaCaT keratinocytes; HECV endotheliocytes and macrophages
RAW 264.7.

Wound healing: in vitro wound healing test using HaCaT keratinocytes and endothelial cells
HECV (D'Agostino et al. 2015, Vergani et al. 2017).

Determination of anti-inflammatory power: inhibition of nitric oxide production in macrophages
RAW 264.7 activated by lipopolysaccharides according to Griess's assay (Yang et al. 2009).

Test su volontari

Test di irritazione cutanea su volontari.

Laboratory Tests

Nickel, GF-AAS title Lead, AAS Cadmium, AAS Zinc, FL-AAS title Cobalt, FL-AAS title
Chromium, GF-AAS, title Mercury, AAS-CVG, title.

Assessment of the maintenance over time of the product's prerogatives for the use for which it was intended
formulated. Stress conditions: ` in thermostat (45°C); ` in refrigerator (2-4°C); ` at temperature
environment (25°C). Main phenomena evaluated: Cremaggio; flocculation; Coalescence; Reversal of
phase, deformation of the packaging. Other surveys that can be evaluated on request: Measurement of pH; Measurement of the
viscosity; Light stability; Thermal shock. The investigation shall last at least one month with
time-distributed deadlines.

The method is based on the determination of the D value, defined as the time, expressed in hours,
necessary to reduce the inoculated micorbic charge by 1 logarithm (i.e. by 90%). The inoculation
is carried out with multiple microbial strains, gram positive, gram negative, yeasts and moulds, as in a
The D value is then corrected according to an index given by the sum of
two factors: the type of packaging in which the product is packaged, and the type of use envisaged for the product.
consumer. This variant of the method also makes it possible to make an assessment of the
shelf life of the product after opening and during use, to suggest suitable packaging or
appropriate instructions for use and post-opening expiry dates based on the specific D-values
found.

Samples Required: 1 sample of 150 ml + INCI Running time: 3 days per inoculum 28 days
incubation 3 days for reading.

Consumer tests

Appreciation and propensity to purchase expected (known price) of my product, based on the only
"concept and established sales price.

Expected enjoyment of my product vs. the competitor. Propensity to purchase expected (known the
price) of my product vs. competitor. Comparison of my product with the competitor, based on the
only "concept" and established sales price of my product.

Attended and real appreceation of my product.
Propensity to purchase expected and real (know the price) of my product. Perceived profile of my
product. Warning point of my product. Image profile of my product, based on 160
samples of the product in real sales packaging.

Expected and real appreciation of my product and competitor.
Propensity to purchase expected and real (known price) of my product and competitor. Distance
I'm sorry, but I'm not the only one who's produced my own product from the competitor. Perceived profile of my product vs. the competitor. Warning point
my product and the competitor. Image profile of my product vs competitor. Based on:
160 samples of your product + 160 samples of your competitor's product in actual packaging of
sales.

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